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Pill Ingredient Could Prevent Brain Damage After Head Injury

A common component of the contraceptive pill (progesterone) could improve the neurologic outcome for patients with severe head injuries, according to a study published in BioMed Central's open access journal Critical Care.

Traumatic brain injury (TBI), such as that caused by traffic accidents, falls and sporting injuries, is a major cause of death and disability. A number of 'neuroprotective' drugs have been shown to prevent nerve-cell death in animal models of traumatic brain injury, but these findings have not been translated into trials involving people with head injuries.

Progesterone is a female hormone used in the oral contraceptive pill. Preliminary animal and human studies suggest that progesterone could be a useful and safe way to treat acute severe traumatic brain injury, but its neuroprotective effects are unclear. Now, Chinese researchers have shown that progesterone can improve the neurologic outcome of patients with this kind of brain injury for up to six months.

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